Priority consideration will be given to Imperial College staff at risk of redundancy
Applications are invited for a Research Associate position in the National Heart and Lung Institute, Faculty of Medicine. The successful applicant will take up a British Heart Foundation-funded post in the laboratory of Dr Ken MacLeod to undertake research into the effects of flecainide on heart cells.
Flecainide, a class Ic anti-arrhythmic, has received a resurgence of interest recently because of high-profile reports describing the clinical benefit of the drug in patients with catecholaminergic polymorphic ventricular tachycardia arising from genetic defects in the cardiac SR Ca2+ release channel (CPVT1) or calsequestrin (CPVT2).
In consultation with the laboratory head you will plan and carry out experiments designed to understand how flecainide and related compounds modulate SR Ca2+ release in heart cells. The studies will involve the use of a variety of electrophysiological, fluorescence and molecular techniques to measure various transmembrane ionic currents and intracellular Ca2+ changes. These studies will form part of a collaborative project between Professor Alan Williams and Dr Chris George at Cardiff University and Dr Ken MacLeod at Imperial College.
You will have a PhD in some aspect of cell physiology and have experience of cellular electrophysiological techniques.
Dr MacLeods laboratory has recently moved to a new building on the Hammersmith Hospital Campus. The move brings together all the NHLI cardiovascular groups in one place for the first time, fostering the beneficial exchange of expertise in state-of-the art facilities.
This post is full-time and fixed-term for 17 months. Informal enquiries to Dr MacLeod (k.t.macleod@imperial.ac.uk) are welcome.
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